验证数据展示
经过测试的应用
Positive IHC detected in | human tonsillitis tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
推荐稀释比
应用 | 推荐稀释比 |
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Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
产品信息
15574-1-AP targets CD11a/Integrin Alpha L in WB, IF, IHC, ELISA applications and shows reactivity with human samples.
经测试应用 | IHC, ELISA Application Description |
文献引用应用 | WB, IF, IHC |
经测试反应性 | human |
文献引用反应性 | human |
免疫原 | CD11a/Integrin Alpha L fusion protein Ag7920 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) |
别名 | CD11A, Integrin alpha L, ITGAL, LFA 1, LFA 1A, LFA1A |
计算分子量 | 129 kDa |
GenBank蛋白编号 | BC008777 |
基因名称 | CD11a |
Gene ID (NCBI) | 3683 |
ENSEMBL Gene ID | ENSG00000005844 |
RRID | AB_2878152 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Antigen affinity purification |
UNIPROT ID | P20701 |
储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
CD11a, also known as integrin αL or LFA-1α, is a 170-180 kDa transmembrane glycoprotein that forms a heterodimer with CD18 (PMID: 7027264; 1672643). CD11a/CD18 (LFA-1) is expressed by all leukocytes and mediates cell adhesion through interactions with its ligands, intercellular adhesion molecule 1 (ICAM-1), ICAM-2, and ICAM-3 (PMID: 7479767). CD11a/CD18 also functions in lymphocyte costimulatory signaling (PMID: 1972160).
实验方案
Product Specific Protocols | |
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IHC protocol for CD11a/Integrin Alpha L antibody 15574-1-AP | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |
发表文章
Species | Application | Title |
---|---|---|
Front Immunol ITGAL expression in non-small-cell lung cancer tissue and its association with immune infiltrates | ||
J Neuroinflammation Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke. | ||
Transl Oncol Quantitative proteomic profiling of hepatocellular carcinoma at different serum alpha-fetoprotein level. |