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LOXL2 Monoclonal antibody, PBS Only

LOXL2 Monoclonal Antibody for WB, IF, IHC, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

Human, rat

Applications

WB, IF, IHC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1H7F1

Cat No : 67139-1-PBS

Print datasheet

Synonyms

LOR2, LOXL2, Lysyl oxidase homolog 2, lysyl oxidase like 2, Lysyl oxidase like protein 2, WS9 14

验证数据展示

  • WB analysis of A549 using 67139-1-Ig (same clone as 67139-1-PBS)

    WB analysis of A549 using 67139-1-Ig (same clone as 67139-1-PBS)

    A549 cells were subjected to SDS PAGE followed by western blot with 67139-1-Ig (LOXL2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67139-1-PBS in a different storage buffer formulation.

  • IF Staining of HepG2 using 67139-1-Ig (same clone as 67139-1-PBS)

    IF Staining of HepG2 using 67139-1-Ig (same clone as 67139-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using 67139-1-Ig (LOXL2 antibody) at dilution of 1:100 and CoraLite488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 67139-1-PBS in a different storage buffer formulation.

  • IHC staining of rat colon using 67139-1-Ig (same clone as 67139-1-PBS)

    IHC staining of rat colon using 67139-1-Ig (same clone as 67139-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat colon tissue slide using 67139-1-Ig (LOXL2 antibody) at dilution of 1:8000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67139-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with LOXL2 antibody included
  • IHC staining of rat colon using 67139-1-Ig (same clone as 67139-1-PBS)

    IHC staining of rat colon using 67139-1-Ig (same clone as 67139-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat colon tissue slide using 67139-1-Ig (LOXL2 antibody) at dilution of 1:8000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 67139-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with LOXL2 antibody included
Planning an IHC experiment? We recommend our IHCeasy LOXL2 Ready-To-Use IHC Kit. LOXL2 primary antibody included.

产品信息

67139-1-PBS targets LOXL2 in WB, IF, IHC, Indirect ELISA applications and shows reactivity with Human, rat samples.

Tested Applications WB, IF, IHC, Indirect ELISA Application Description
Tested Reactivity Human, rat
Immunogen LOXL2 fusion protein Ag28566 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name lysyl oxidase-like 2
Synonyms LOR2, LOXL2, Lysyl oxidase homolog 2, lysyl oxidase like 2, Lysyl oxidase like protein 2, WS9 14
Calculated Molecular Weight 774 aa, 87 kDa
Observed Molecular Weight 100 kDa
GenBank Accession NumberBC000594
Gene Symbol LOXL2
Gene ID (NCBI) 4017
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ9Y4K0
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

背景介绍

LOXL2, also named as WS9-14, belongs to an amine oxidase family whose members have been implicated in crosslink formation in stromal collagens and elastin, cell motility, and tumor development and progression. LOXL2 activity might be a crucial modulator of Snail, providing an additional control mechanism of EMT and tumor progression. Increased LOXL2 expression in colon and esophageal cancer may contribute to tumor progression. We detected a band about 100 kd which is a secretory mature LOXL2 protein modified by glycosylation (PMID: 24014025).