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LRP4 Polyclonal antibody

LRP4 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 24434-1-AP

Print datasheet

Synonyms

KIAA0816, LRP 4, LRP10, LRP4, MEGF7

验证数据展示

  • WB analysis using 24434-1-AP

    WB analysis using 24434-1-AP

    Mouse brain tissue was subjected to SDS PAGE followed by western blot with 24434-1-AP (LRP4 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

经过测试的应用

Positive WB detected inmouse brain tissue

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

24434-1-AP targets LRP4 in WB, ELISA applications and shows reactivity with human samples.

Tested Applications WB, ELISA Application Description
Tested Reactivity human
Immunogen LRP4 fusion protein Ag19487 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name low density lipoprotein receptor-related protein 4
Synonyms KIAA0816, LRP 4, LRP10, LRP4, MEGF7
Calculated Molecular Weight 1905 aa, 212 kDa
Observed Molecular Weight240 kDa
GenBank Accession NumberBC136667
Gene Symbol LRP4
Gene ID (NCBI) 4038
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDO75096
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

LRP4 (low-density lipoprotein receptor-related protein 4), also known as multiple epidermal growth factor-like domains 7 (MEGF7), is a type I single transmembrane protein of the low-density lipoprotein receptor (LDLR) family. LRP4 is composed of a large extracellular region containing multiple LDLa repeats, EGF-like domains and β-propeller domains, a transmembrane region and a cytoplasmic region containing an NPxY motif and a PDZ-interacting motif (PMID: 26071838). LRP4 binds agrin and recruits it to the MuSK signaling complex, which is critical for neuromuscular junction formation (PMID: 17119023; 18957220). LPR4 mutation or malfunction is implicated in disorders including congenital myasthenic syndrome, myasthenia gravis, and diseases of bone or kidney (26071838).

实验方案

Product Specific Protocols
WB protocol for LRP4 antibody 24434-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols