验证数据展示
经过测试的应用
| Positive WB detected in | HeLa cells, mouse heart tissue, rat bone marrow tissue, rat spleen tissue, rat thymus tissue |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:200-1:1000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
发表文章中的应用
| KD/KO | See 1 publications below |
| WB | See 2 publications below |
产品信息
20918-1-AP targets LRRC17 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, ELISA Application Description |
| 文献引用应用 | WB |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, mouse |
| 免疫原 | LRRC17 fusion protein Ag15117 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | leucine rich repeat containing 17 |
| 别名 | UNQ3076/PRO9909, p37NB, Leucine-rich repeat-containing protein 17 |
| 计算分子量 | 441 aa, 52 kDa |
| 观测分子量 | 52 kDa |
| GenBank蛋白编号 | BC027903 |
| 基因名称 | LRRC17 |
| Gene ID (NCBI) | 10234 |
| RRID | AB_2878763 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen Affinity purified |
| UNIPROT ID | Q8N6Y2 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Leucine-rich repeat-containing protein 17 (LRRC17) is an LRR protein predominantly expressed by osteoblasts. LRRC17 acts as a negative regulator of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation (PMID: 19336404). It has been reported that low plasma level of LRRC17 is an independent risk factor for osteoporotic fractures (PMID: 27355564).
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for LRRC17 antibody 20918-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
发表文章
| Species | Application | Title |
|---|---|---|
Redox Biol LRRc17 controls BMSC senescence via mitophagy and inhibits the therapeutic effect of BMSCs on ovariectomy-induced bone loss. | ||
Exp Ther Med LRRC17 regulates the bone metabolism of human bone marrow mesenchymal stem cells from patients with idiopathic necrosis of femoral head through Wnt signaling pathways: A preliminary report.
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