验证数据展示
发表文章中的应用
| WB | See 1 publications below |
| IHC | See 4 publications below |
产品信息
17708-1-AP targets LTBP2 in WB, IF, IHC, ELISA applications and shows reactivity with human samples.
| 经测试应用 | IF, ELISA Application Description |
| 文献引用应用 | WB, IHC |
| 经测试反应性 | human |
| 文献引用反应性 | human, mouse |
| 免疫原 | LTBP2 fusion protein Ag12007 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | latent transforming growth factor beta binding protein 2 |
| 别名 | C14orf141, LTBP 2, LTBP2, LTBP3, MSTP031 |
| 计算分子量 | 1821 aa, 195 kDa |
| GenBank蛋白编号 | BC078659 |
| 基因名称 | LTBP2 |
| Gene ID (NCBI) | 4053 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q14767 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
LTBP2, a 240 kDa extracellular glycoprotein mapping to chromosome 14q24, belongs to a family of latent TGF-βbinding proteins (LTBPs) that regulates a well-known growth factor, TGF-β. LTBP2 is an elastic fiber-associating protein whose function in elastogenesis is not clear, as a DANCE binding Protein. It may play an integral structural role in elastic-fiber architectural organization and/or assembly. LTBP2 associates covalently with small latent TGF-beta complex via Repeat B and Repeat C. Defects in LTBP2 are the cause of primary congenital glaucoma type 3D (GLC3D). LTBP2 is a role in the structural stability of ciliary zonules, and growth and development of lens. LTBP2 null mutations in an autosomal recessive ocular syndrome with megalocornea, spherophakia, and secondary glaucoma. LTBP2 is a biomarker of heart failure.
发表文章
| Species | Application | Title |
|---|---|---|
Clin Sci (Lond) LTBP2 is secreted from lung myofibroblasts and is a potential biomarker for idiopathic pulmonary fibrosis. | ||
Am J Transl Res LTPB2 acts as a prognostic factor and promotes progression of cervical adenocarcinoma. | ||