• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

LTBP2 Recombinant antibody, PBS Only

LTBP2 Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

241911C7

Cat no : 84574-4-PBS

Print datasheet

Synonyms

LTBP3, C14orf141, 241911C7, LTBP-2, LTBP 2

验证数据展示

  • WB analysis using 84574-4-RR (same clone as 84574-4-PBS)

    WB analysis using 84574-4-RR (same clone as 84574-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84574-4-RR (LTBP2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84574-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84574-4-RR

    Affinity and Kinetic Characterization of 84574-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84574-4-RR against Human LTBP2 were performed. The affinity constant is 0.779 nM.

产品信息

84574-4-PBS targets LTBP2 in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human
Immunogen LTBP2 fusion protein Ag29720 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name latent transforming growth factor beta binding protein 2
Synonyms LTBP3, C14orf141, 241911C7, LTBP-2, LTBP 2
Calculated Molecular Weight 1821 aa, 195 kDa
Observed Molecular Weight290 kDa
GenBank Accession NumberBC078659
Gene Symbol LTBP2
Gene ID (NCBI) 4053
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ14767
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

LTBP2, an extracellular glycoprotein mapping to chromosome 14q24, belongs to a family of latent TGF-β binding proteins (LTBPs) that regulates a well-known growth factor, TGF-β. LTBP2 is an elastic fiber-associating protein whose function in elastogenesis is not clear, as a DANCEbinding Protein. (PMID: 17581631 )It may play an integral structural role in elastic-fiber architectural organization and/or assembly. LTBP2 associates covalently with small latent TGF-beta complex via Repeat B and Repeat C. Defects in LTBP2 are the cause of primary congenital glaucoma type 3D (GLC3D). [MIM:613086] LTBP2 is a role in the structural stability of ciliary zonules, and growth and development of lens.(PMID: 20617341) LTBP2 null mutations in an autosomal recessive ocular syndrome with megalocornea, spherophakia, and secondary glaucoma (PMID: 20179738 ) . LTBP2 is a biomarker of heart failure. LTBP2 has a molecular weight of 260 kDa (PMID: 20878956), and even larger molecular weights of 290 and 310 kDa were detected in tissue extracts. (PMID: 8524260)