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LYN-1604 dihydrochloride

LYN-1604 2HCl 是一种有效的 UNC-51 样激酶 1 激活剂，EC50值为 18.94 nM。LYN-1604 可研究三阴性乳腺癌。

CAS号

2310109-38-5

分子式

C33H45Cl4N3O2

主要靶点

Apoptosis|Autophagy

仅限科研使用

Cat No : CM14414

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Synonyms

LYN-1604 2HCl（2216753-86-3 free base)

验证数据展示

  • CAS No.: 2310109-38-5

    LYN-1604 dihydrochloride
    CAS#: 2310109-38-5

产品信息

LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.

CAS号 2310109-38-5
分子式 C33H45Cl4N3O2
主要靶点 Apoptosis|Autophagy
主要通路 凋亡|自噬
分子量 657.54
纯度 99.80%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 LYN-1604 2HCl（2216753-86-3 free base)

靶点活性

ULK1:18.94 nM (EC50)

体外活性

LYN-1604, to be the best candidate for a ULK1 agonist.?LYN-1604 induced cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.?LYN-1604 has potential for good therapeutic effects on TNBC by targeting ULK1-modulated cell death in vivo

溶解度

DMSO:25 mg/mL (38.02 mM)

参考文献

1.Zhang L , Fu L , Zhang S , et al. Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo[J]. Chemical Science, 2017, 8(4):2687.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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