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  • KD/KO Validated

LZTS2 Polyclonal antibody

LZTS2 Polyclonal Antibody for WB, IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, ELISA and More (2)

Conjugate

Unconjugated

Cat no : 15677-1-AP

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Synonyms

hLZTS2, KIAA1813, LAPSER1, LZTS2, Protein LAPSER1



经过测试的应用

Positive WB detected inHeLa cells, PC-3 cells
Positive IHC detected inhuman prostate hyperplasia tissue, human kidney tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:8000
Immunohistochemistry (IHC)IHC : 1:20-1:200
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

15677-1-AP targets LZTS2 in WB, IP, IF, IHC, ELISA applications and shows reactivity with human, mouse samples.

Tested Applications WB, IHC, ELISA Application Description
Cited ApplicationsWB, IP, IF
Tested Reactivity human, mouse
Cited Reactivityhuman
Immunogen LZTS2 fusion protein Ag8145 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name leucine zipper, putative tumor suppressor 2
Synonyms hLZTS2, KIAA1813, LAPSER1, LZTS2, Protein LAPSER1
Calculated Molecular Weight 73 kDa
Observed Molecular Weight 70-80 kDa
GenBank Accession NumberBC006212
Gene Symbol LZTS2
Gene ID (NCBI) 84445
RRIDAB_2878166
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9BRK4
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

LZTS2, also named as KIAA1813 and LAPSER1, is a novel b-Catenin-interacting protein and it regulates the nuclear export of b-Catenin. LZTS2 is a negative regulator of katanin-mediated microtubule severing and release from the centrosome. It is required for central spindle formation and the completion of cytokinesis.

实验方案

Product Specific Protocols
WB protocol for LZTS2 antibody 15677-1-APDownload protocol
IHC protocol for LZTS2 antibody 15677-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
IF

Nat Commun

Proximity proteomics identifies PAK4 as a component of Afadin-Nectin junctions.

Authors - Yohendran Baskaran
humanWB,IP

Oncogene

β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.

Authors - Yanwei Lu
  • KD Validated
humanWB

Cancer Lett

LZTS2 inhibits PI3K/AKT activation and radioresistance in nasopharyngeal carcinoma by interacting with p85.

Authors - Shuangbing Xu
  • KD Validated
humanWB,IF

bioRxiv

α-catenin mechanosensitivity as a route to cytokinesis failure through sequestration of LZTS2

Authors - Yuou Wang
  • KD Validated
humanWB,IP

Cell Signal

Phosphorylation of LZTS2 by PLK1 activates the Wnt pathway

Authors - Ran Liu
humanWB

Cell Death Dis

RRP15 deficiency induces ribosome stress to inhibit colorectal cancer proliferation and metastasis via LZTS2-mediated β-catenin suppression

Authors - Zhixiong Dong