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Liproxstatin-1

Liproxstatin-1 是一种铁死亡抑制剂，IC50为22 nM。

CAS号

950455-15-9

分子式

C19H21ClN4

主要靶点

Ferroptosis

仅限科研使用

Cat No : CM04076

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Synonyms

验证数据展示

  • CAS No.: 950455-15-9

    Liproxstatin-1
    CAS#: 950455-15-9

产品信息

Liproxstatin-1 is a potent ferroptosis inhibitor.

CAS号 950455-15-9
分子式 C19H21ClN4
主要靶点 Ferroptosis
主要通路 凋亡
分子量 340.85
纯度 99.44%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

ferroptosis:22 nM

体内活性

Liproxstatin-1（200 nM）以剂量依赖的方式保护免受FINs（例如BSO（10 μM）,erastin（1 μM）和RSL3（0.5 μM））诱发的细胞死亡,而不能阻断由0.2 μM 十字孢碱和200 μM H2O2诱发的细胞死亡。Liproxstatin-1能够在低纳摩尔范围内抑制铁死亡,并抑制Gpx4 -/- 细胞的生长,IC50为22 nM。Liproxstatin-1（50 nM）完全防止Gpx4 -/- 细胞的脂质过氧化。

体外活性

Liproxstatin-1与溶剂对照组相比,可明显地延长生存期,抑制小管上皮细胞中铁死亡,并减轻了局部缺血/再灌注引起的肝损伤中的组织损伤.

溶解度

Ethanol:soluble,DMSO:60 mg/ml (176.03 mM),H2O:Insoluble

细胞实验

Cell viability is assessed at different time points after treatment using AquaBluer according to the manufacturer’s recommendations. Alternatively, cell death is also quantified by measuring released lactate dehydrogenase activity using the cytotoxicity detection kit (LDH). (Only for Reference)

参考文献

1.Friedmann Angeli JP, et al. Nat Cell Biol. 2014, 16(12):1180-1191.
2.Su G, Yang W, Wang S, et al. SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Β and IL-18[J]. Biochemical and Biophysical Research Communications. 2021, 561: 33-39.
3.Rui T, Wang H, Li Q, et al. Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury‐induced ferroptosis[J]. Journal of Pineal Research. 2020: e12704.

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