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Lusianthridin

Lusianthridin 是来自石斛 Dendrobium venustum 的天然产物。 Lusianthridin 在无毒浓度下表现出抗迁移特性。 Lusianthridin 通过抑制 Src-STAT3 信号传导增强 c-Myc 降解。

CAS号

87530-30-1

分子式

C15H14O3

主要靶点

Others|c-Myc

仅限科研使用

Cat No : CM18894

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Synonyms

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  • CAS No.: 87530-30-1

    Lusianthridin
    CAS#: 87530-30-1

产品信息

Lusianthridin is a natural product from Dendrobium venustum. Lusianthridin exhibits anti-migratory property at nontoxic concentrations. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling.

CAS号 87530-30-1
分子式 C15H14O3
主要靶点 Others|c-Myc
主要通路 其他|细胞周期
分子量 242.27
纯度 99.11%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体外活性

Lusianthridin showed appreciable cytotoxicity against human lung cancer cell lines with IC50 values of 65.0 μg/mL[1]. Lusianthridin (0-100 μM) inhibited cell viability at concentrations greater than 50 μM in both H460 and H292 cells[2]. Lusianthridin significantly reduced the CSC populations in both H460 and H292 cells of the CSC spheres, with a significant decrease in the size of the H460 CSC spheres by approximately 10%, 63%, and 77% at day 3 at concentrations of 5, 10, and 20 μM, respectively[2].

参考文献

1.Cytotoxic and Antimigratory Activities of Phenolic Compounds from Dendrobium brymerianum.Evid Based Complement Alternat Med. 2015;2015:350410.
2.Narumol Bhummaphan, et al. Targeting of Lung Cancer Stem Cells via Src-STAT3 Suppression. Phytomedicine. 2019 Sep;62:152932.

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