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MEF2C Polyclonal antibody, PBS Only

MEF2C Polyclonal Antibody for WB, IHC, IF-P, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IF-P, Indirect ELISA

Conjugate

Unconjugated

Cat no : 20326-1-PBS

Print datasheet

Synonyms

验证数据展示

  • WB analysis of HeLa using 20326-1-AP (same clone as 20326-1-PBS)

    WB analysis of HeLa using 20326-1-AP (same clone as 20326-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 20326-1-AP (MEF2C antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 20326-1-PBS in a different storage buffer formulation.

  • IHC staining of human heart using 20326-1-AP (same clone as 20326-1-PBS)

    IHC staining of human heart using 20326-1-AP (same clone as 20326-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human heart slide using 20326-1-AP (MEF2C Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 20326-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with MEF2C antibody included
  • IHC staining of human heart using 20326-1-AP (same clone as 20326-1-PBS)

    IHC staining of human heart using 20326-1-AP (same clone as 20326-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human heart slide using 20326-1-AP (MEF2C Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 20326-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with MEF2C antibody included
  • IF Staining of mouse brain using 20326-1-AP (same clone as 20326-1-PBS)

    IF Staining of mouse brain using 20326-1-AP (same clone as 20326-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using MEF2C antibody (20326-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 20326-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse brain using 20326-1-AP (same clone as 20326-1-PBS)

    IF Staining of mouse brain using 20326-1-AP (same clone as 20326-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed mouse brain tissue using MEF2C antibody (20326-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 20326-1-PBS in a different storage buffer formulation.

Planning an IHC experiment? We recommend our IHCeasy MEF2C Ready-To-Use IHC Kit. MEF2C primary antibody included.

产品信息

20326-1-PBS targets MEF2C in WB, IHC, IF-P, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Applications WB, IHC, IF-P, Indirect ELISA Application Description
Tested Reactivity human, mouse, rat
Immunogen MEF2C fusion protein Ag13255 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name myocyte enhancer factor 2C
Synonyms
Calculated Molecular Weight 469 aa, 51 kDa
Observed Molecular Weight45-70 kDa
GenBank Accession NumberBC026341
Gene Symbol MEF2C
Gene ID (NCBI) 4208
RRIDAB_10693772
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ06413
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

MEF2C belongs to the MEF2 family. It is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. MEF2C controls cardiac morphogenesis and myogenesis, and is also involved in vascular development[PMID: 20221419]. It plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission[PMID:18599438]. It is crucial for normal neuronal development, distribution, and electrical activity in the neocortex and is necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis[PMID: 21666133]. This protein is required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. It may also be involved in neurogenesis and in the development of cortical architecture. MEF2C exists some isoforms with MV 50-52 kDa, 47 kDa, and 45 kDa, but modified MEF2C is about 55-66 kDa.