METTL6 Recombinant antibody, PBS Only
METTL6 Uni-rAbTM Recombinant Antibody for IF/ICC, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
IF/ICC, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
241482F9
验证数据展示
产品信息
The immunogen of 84209-5-PBS is METTL6 Fusion Protein expressed in E. coli.
Tested Applications | IF/ICC, Indirect ELISA Application Description |
Tested Reactivity | human |
Immunogen | METTL6 fusion protein Ag9714 种属同源性预测 |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Full Name | methyltransferase like 6 |
Synonyms | tRNA N(3)-methylcytidine methyltransferase METTL6, Methyltransferase-like protein 6, methyltransferase like 6, hMETTL6, EC:2.1.1.- |
Calculated Molecular Weight | 255 aa, 30 kDa |
GenBank Accession Number | BC022400 |
Gene Symbol | METTL6 |
Gene ID (NCBI) | 131965 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purfication |
UNIPROT ID | Q8TCB7 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Methyltransferase-like protein 6 (METTL6) belongs to the METL family. METTL6 is as a crucial regulator of tumor cell growth, and METTL6 is a bona fide transfer RNA (tRNA) methyltransferase, catalyzing the formation of 3-methylcytidine at C32 of specific serine tRNA isoacceptors (PMID:32923617). METTL6 is a member of the RNA methyltransferase family that has been identified in many cancers. The mRNA expression levels of METTL6 were significantly upregulated in HCC tumor tissues compared to that in adjacent nontumor tissues. CRISPR/Cas9mediated knockout of METTL6 in hepatocellular carcinoma cell lines remarkably inhibited colony formation, cell proliferation, cell migration, cell invasion and cell attachment ability (PMID:34913069).