验证数据展示
产品信息
66384-1-PBS targets MICA in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.
Tested Applications | WB, IHC, Indirect ELISA Application Description |
Tested Reactivity | human |
Immunogen | MICA fusion protein Ag3298 种属同源性预测 |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Full Name | MHC class I polypeptide-related sequence A |
Synonyms | MIC A, MICA, PERB11.1 |
Calculated Molecular Weight | 383 aa, 43 kDa |
Observed Molecular Weight | 43-50 kDa |
GenBank Accession Number | BC016929 |
Gene Symbol | MICA |
Gene ID (NCBI) | 100507436 |
RRID | AB_2881760 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q29983 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Human MHC class I chain-related genes located within the HLA class I region of chromosome 6 encode MHC class I chain-related A and B (MICA and MICB) (PMID: 11429322). MICA and MICB are stress-inducible surface molecules that are not associated with β2-microglobulin and do not present peptides (PMID: 9497295). They are expressed in intestinal epithelium and many epithelial tumors (PMID: 10359807). MICA and MICB are ligands for NKG2D which is an activating receptor that is expressed on most natural killer (NK) cells, CD8 αβ T cells, and γδ T cells (PMID: 10426993, 11491531).