Anti-Human MICA/MICB (6D4) Mouse IgG2a Recombinant Antibody, PBS Only
MICA/MICB Recombinant Antibody for FC
Host / Isotype
Mouse / IgG2a
Reactivity
human
Applications
FC
Conjugate
Unconjugated
CloneNo.
6D4
验证数据展示
产品信息
65589-1-PBS targets MICA/MICB in FC applications and shows reactivity with human samples.
| Tested Applications | FC Application Description |
| Tested Reactivity | human |
| Immunogen | Transfected C1R cells expressing MICA 种属同源性预测 |
| Host / Isotype | Mouse / IgG2a |
| Class | Recombinant |
| Type | Antibody |
| Full Name | MHC class I polypeptide-related sequence A |
| Synonyms | MICA, MIC-A, MIC A, 6D4 |
| Calculated Molecular Weight | 383 aa, 43 kDa |
| GenBank Accession Number | BC016929 |
| Gene Symbol | MICA |
| Gene ID (NCBI) | 100507436 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Human MHC class I chain-related genes located within the HLA class I region of chromosome 6 encode MHC class I chain-related A and B (MICA and MICB) (PMID: 11429322). MICA and MICB are stress-inducible surface molecules that are not associated with β2-microglobulin and do not present peptides (PMID: 9497295). They are expressed in intestinal epithelium and many epithelial tumors (PMID: 10359807). MICA and MICB are ligands for NKG2D which is an activating receptor that is expressed on most natural killer (NK) cells, CD8 αβ T cells, and γδ T cells (PMID: 10426993; 11491531). The monoclonal antibody 6D4 recognizes MICA and MICB.