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MIST1 Monoclonal antibody, PBS Only

MIST1 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

Human, Pig, Rat , Mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

1E10B3

Cat no : 68092-1-PBS

Print datasheet

Synonyms

BHLHA15, MIST 1, MIST1

验证数据展示

  • WB analysis using 68092-1-Ig (same clone as 68092-1-PBS)

    WB analysis using 68092-1-Ig (same clone as 68092-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68092-1-Ig (MIST1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68092-1-PBS in a different storage buffer formulation.

产品信息

68092-1-PBS targets MIST1 in WB, Indirect ELISA applications and shows reactivity with Human, Pig, Rat , Mouse samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity Human, Pig, Rat , Mouse
Immunogen MIST1 fusion protein Ag18509 种属同源性预测
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Full Name basic helix-loop-helix family, member a15
Synonyms BHLHA15, MIST 1, MIST1
Calculated Molecular Weight 189 aa, 21 kDa
Observed Molecular Weight27 kDa
GenBank Accession NumberBC113394
Gene Symbol MIST1
Gene ID (NCBI) 168620
RRIDAB_2918829
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ7RTS1
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Muscle intestine stomach expression 1 (MIST1), also named bHLHa15, is a secretory cell transcription factor that belongs to the basic helix-loop-helix superfamily. MIST1 is mainly expressed in serous secreted cells and essential for the development and maturation of secretory cells. Secretory cells lacking MIST1 exhibit structural and functional defects, including alterations in cytoskeletal organization and cell polarity and improper cell-cell junction. In healthy pancreata, MIST1 facilitates cell-to-cell communication, promotes acinar cell polarity, controls Ca2+ flux, promotes unfolded protein response (UPR) homeostasis, aids in vesicle assembly, and is required for regulated exocytosis. MIST1 was downregulated in pancreatic cancer tissues compared with normal or adjacent pancreatic tissues and lower MIST1 expression in pancreatic cancer cell lines than normal acinar cells (BxPC-3, PANC-1, SW 1990) (PMID:29859299). MIST1 is downregulated in the development of gastric cancer and in gastric cancer cells compared with SW620 cells (PMID:34149921).