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MPTP hydrochloride

MPTP hydrochloride (MPTP-hydrochloride) 是 MPPp 的前体，它对多巴胺能神经元有毒并导致帕金森症。可以诱导凋亡作用。

CAS号

23007-85-4

分子式

C12H16ClN

主要靶点

Apoptosis|Dopamine Receptor

仅限科研使用

Cat No : CM01173

Print datasheet

Synonyms

MPTP-hydrochloride

验证数据展示

  • CAS No.: 23007-85-4

    MPTP hydrochloride
    CAS#: 23007-85-4

产品信息

MPTP-hydrochloride is a precusor of MPP+ which is toxic to dopaminergic neurons and causes Parkinsonism.

CAS号 23007-85-4
分子式 C12H16ClN
主要靶点 Apoptosis|Dopamine Receptor
主要通路 G蛋白偶联受体|凋亡|神经科学
分子量 209.72
纯度 100.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 MPTP-hydrochloride

体内活性

The toxic effect of MPTP can be completely abolished in vivo by treatment with a monoamine oxidase inhibitor and potentiated by an inhibitor of catechol-O-methyltransferase[1]. Allopurinol potentiated the MPTP (35 mg/kg)-induced decrease in the DOPAC+HVA/DA ratio and increase in striatal AA oxidation of the rat[2]. Gas1 expressions are significantly elevated in the majority of the reactive astrocytes of the brains with LPS or MPTP insults in animal models[4].

体外活性

Pretreatment with 50 mM 4-phenylpyridine, reduces IC50 (concentration for 50% inhibition of twitch amplitude) values of MPTP from 53 to 18 mM and d-tubocurarine from 0.7 to 0.3 mM, respectively, in mouse phrenic nerve-diaphragm[3].

溶解度

DMSO:12 mg/mL,H2O:10mg/mL

参考文献

1.Langston J W, Irwin I. MPTP Neurotoxicity: An Overview and Characterization of Phases of Toxicity. II. Selective Accumulation of MPP in the Substantia Nigra: A Key to Neurotoxicity (Question). Life Sci., 1985, 36, No. 3, 201-12.
2.Desole M S, et al. Further investigation of allopurinol effects on MPTP-induced oxidative stress in the striatum and brain stem of the rat. Source:Pharmacol.Biochem.Behav., 1996, 54, No. 2, 377-83.
3.Hsu K S, et al. Potentiation of MPTP by 4-Phenylpyridine on the Neuromuscular Blockade in Mouse Phrenic Nerve-Diaphragm. Neuropharmacology, 1993, 32, No. 9, 877-83.
4.Sun XL, et al. Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models. J Neuroinflammation. 2016 Jul 8;13(1):180.

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