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MRG15 antibody (pAb)

Host / Isotype

Rabbit / IgG

Reactivity

Human, Wide Range Predicted

Applications

WB

Cat No : 39361,39362 39361

Synonyms

hEaf3, MORF4L1, MORFRG15, NuA4, MORF-related gene, Eaf3, chromodomain, pAb, polyclonal, MORF4-Related Gene on chromosome 15, antibody, antibodies, sample

验证数据展示

  • MRG15 pAb tested by Western blot. Nuclear extract of HeLa cells (20 ug) was probed with MRG15 pAb (1:500 dilution).

    MRG15 pAb tested by Western blot. Nuclear extract of HeLa cells (20 ug) was probed with MRG15 pAb (1:500 dilution).

产品信息

Tested Applications WB

Applications Validated by Active Motif: WB: 1:250 - 1:1,000 dilution
Tested Reactivity Human, Wide Range Predicted
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen This MRG15 antibody was raised against a peptide corresponding to the C-terminus of human MRG15.
Full Name MRG15 antibody (pAb)
Synonyms hEaf3, MORF4L1, MORFRG15, NuA4, MORF-related gene, Eaf3, chromodomain, pAb, polyclonal, MORF4-Related Gene on chromosome 15, antibody, antibodies, sample
Molecular weight 39 kDa
GenBank accession numberNP_996670
RRIDAB_2615022
Purification Method Affinity Purified
Buffer Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

背景介绍

MRG15 (MORF4-Related Gene on chromosome 15) is the homolog of the yeast Eaf3 protein and belongs to the MRG family of genes, which are involved in various cellular processes as cellular aging, positive and negative transcriptional regulation and DNA damage repair. MRG15 can be associated with both histone deacetylase and histone acetyltransferase complexes (such as the NuA4 histone acetyltransferase complex, which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal Histone H2A and Histone H4). MRG15, thus, potentially plays a role in both transcriptional silencing and activation. In addition to the more conserved MRG motifs, MRG15 also contains a chromodomain near the N-terminus.