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MRP1 Monoclonal antibody, PBS Only

MRP1 Monoclonal Antibody for WB,ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB,ELISA

Conjugate

Unconjugated

CloneNo.

1G4A2

Cat No : 67228-1-PBS

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Synonyms

ABC29, ABCC, ABCC1, Leukotriene C(4) transporter, LTC4 transporter, MRP, MRP1

验证数据展示

  • WB analysis using 67228-1-Ig (same clone as 67228-1-PBS)

    WB analysis using 67228-1-Ig (same clone as 67228-1-PBS)

    Non-boil and boiled HepG2 and A549 cell lysates were subjected to SDS PAGE followed by western blot with 67228-1-Ig (ABCC1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. Left panel was exposed for 20 sec. and right panel was exposed for 1 min. This data was developed using the same antibody clone with 67228-1-PBS in a different storage buffer formulation.

产品信息

67228-1-PBS targets MRP1 in WB, ELISA applications and shows reactivity with Human samples.

Tested Applications WB,ELISA Application Description
Tested Reactivity Human
Immunogen MRP1 fusion protein Ag27048 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Synonyms ABC29, ABCC, ABCC1, Leukotriene C(4) transporter, LTC4 transporter, MRP, MRP1
Calculated Molecular Weight 172 kDa
Observed Molecular Weight 180-190 kDa
GenBank Accession NumberNM_004996
Gene Symbol ABCC1
Gene ID (NCBI) 4363
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP33527
Storage Buffer PBS only
Storage ConditionsStore at -80°C.

背景介绍

Multidrug resistant-associated protein 1 (MRP1; ABCC1) is a member of the ATP-binding cassette (ABC) transporter protein superfamily, subfamily C. MRP1 is overexpressed in cancers and contributes to the occurrence of multidrug resistance (MDR). Expression of MRP1 has been considered as a negative marker for the outcome of chemotherapy. Recently MRP1 has been reported to play a crucial role in Aβ clearance at the blood-brain barrier.