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MS023

MS023 是一种有效的、选择性的、细胞活性的 I 型 PRMT 抑制剂，对 PRMT1、PRMT3、PRMT4、PRMT6和 PRMT8的 IC50分别为 30、119、83、4 和 5 nM。

CAS号

1831110-54-3

分子式

C17H25N3O

主要靶点

Histone Methyltransferase

仅限科研使用

Cat No : CM04575

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Synonyms

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  • CAS No.: 1831110-54-3

    MS023
    CAS#: 1831110-54-3

产品信息

MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively.

CAS号 1831110-54-3
分子式 C17H25N3O
主要靶点 Histone Methyltransferase
主要通路 表观遗传
分子量 287.4
纯度 99.28%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

PRMT8:5 nM|PRMT1:30 nM|PRMT4:83 nM|PRMT6:4 nM|PRMT3:119 nM

体外活性

MS023 potently reduces cellular levels of H4R3me2a in MCF7 and HEK293 cells by inhibiting PRMT1/6 methyltransferase activity with IC50 of 9 nM and 56 nM, respectively. MS023 also inhibits cell growth and potentially induces growth arrest and flattening morphology at low concentrations. [1]

溶解度

Ethanol:53 mg/mL (184.4 mM),DMSO:53 mg/mL (184.4 mM),H2O:<1 mg/mL

参考文献

1.Eram MS, et al. ACS Chem Biol. 2016, 11(3), 772-781.

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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2