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MTMR2 Monoclonal antibody

MTMR2 Monoclonal Antibody for WB, ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

Human, Pig

Applications

WB, ELISA

Conjugate

Unconjugated

CloneNo.

1B11B7

Cat no : 67312-1-Ig

Print datasheet

Synonyms

CMT4B, CMT4B1, KIAA1073, MTMR2, myotubularin related protein 2

验证数据展示

  • WB analysis of HeLa using 67312-1-Ig

    WB analysis of HeLa using 67312-1-Ig

    HeLa cells were subjected to SDS PAGE followed by western blot with 67312-1-Ig (MTMR2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

  • WB analysis of HeLa using 67312-1-Ig

    WB analysis of HeLa using 67312-1-Ig

    WB result of MTMR2 antibody (67312-1-Ig; 1:2000; incubated at room temperature for 1.5 hours) with sh-Control and sh-MTMR2 transfected HeLa cells.

经过测试的应用

Positive WB detected inHeLa cells, pig brain tissue, HEK-293 cells, Jurkat cells

推荐稀释比

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:6000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

67312-1-Ig targets MTMR2 in WB, ELISA applications and shows reactivity with Human, Pig samples.

Tested Applications WB, ELISA Application Description
Tested Reactivity Human, Pig
Immunogen MTMR2 fusion protein Ag28413 种属同源性预测
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Full Name myotubularin related protein 2
Synonyms CMT4B, CMT4B1, KIAA1073, MTMR2, myotubularin related protein 2
Calculated Molecular Weight 73 kDa
Observed Molecular Weight 66-73 kDa
GenBank Accession NumberBC052990
Gene Symbol MTMR2
Gene ID (NCBI) 8898
RRIDAB_2882572
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDQ13614
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

MTMR2(myotubularin-related protein 2) is also named as KIAA1073 and belongs to the non-receptor class myotubularin subfamily, which is characterized by the presence of a phosphatase domain. It may regulate vesicular trafficking in Schwann cells (PMID:17880751) and its reversible phosphorylation represents a critical mechanism for regulating the subcellular localization of MTMR2(PMID:21372139). MTMR2 is a 73 kDa protein in its monomeric form and exist as a dimer within cells and the protein re-localizes to membranes in hypo-osmotic settings(PMID:16399794). Defects in MTMR2 are the cause of Charcot-Marie-Tooth disease type 4B1 (CMT4B1). MTMR2 has two isofroms with the molecular mass of 73 and 66 kDa.

实验方案

Product Specific Protocols
WB protocol for MTMR2 antibody 67312-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols