验证数据展示
产品信息
67996-1-PBS targets MYBBP1A in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.
经测试应用 | WB, IHC, IF/ICC, Indirect ELISA Application Description |
经测试反应性 | Human, mouse, rat |
免疫原 | MYBBP1A fusion protein Ag6008 种属同源性预测 |
宿主/亚型 | Mouse / IgG1 |
抗体类别 | Monoclonal |
产品类型 | Antibody |
全称 | MYB binding protein (P160) 1a |
别名 | FLJ37886, MYB binding protein (P160) 1a, Myb binding protein 1A, MYBBP1A, P160, PAP2 |
计算分子量 | 149 kDa |
观测分子量 | 140 kDa |
GenBank蛋白编号 | BC050546 |
基因名称 | MYBBP1A |
Gene ID (NCBI) | 10514 |
RRID | AB_2918745 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein G purification |
UNIPROT ID | Q9BQG0 |
储存缓冲液 | PBS Only |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
The protooncogene MYB is predominantly expressed in immature hemopoietic cells where it has an essential role in hemopoietic cell proliferation and differentiation. Oncogenically activated forms of MYB is generally N- and/or C-terminal truncations of the normal MYB protein. Removal of the C terminus of MYB disrupts or deletes a region termed the negative regulatory domain (NRD), resulting in an increase in DNA binding, transactivation, and transformation by MYB. One feature of the NRD is a leucine zipper-like motif [PMID: 8302594]. Murine Myb-binding protein-1a (MYBBP1A), originally called P160, was identified by its ability to interact specifically with Myb via this leucine zipper-like motif. MYBBP1A modulates MYB activity upon binding to the MYB NRD [PMID: 10644447, 9447996].