c-Myc Polyclonal antibody
c-Myc Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat
Applications
ELISA and More (1)
Conjugate
Unconjugated
验证数据展示
经过测试的应用
推荐稀释比
| Application | Dilution |
|---|---|
| Sample-dependent, check data in validation data gallery | |
发表文章中的应用
| WB | See 10 publications below |
产品信息
10057-1-AP targets c-Myc in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Applications | ELISA |
| Cited Applications | WB |
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human, mouse, rat |
| Immunogen | Recombinant Protein |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Full Name | v-myc myelocytomatosis viral oncogene homolog (avian) |
| Synonyms | bHLHe39, c Myc, c-Myc, MRTL, MYC, Myc proto oncogene protein, Proto oncogene c Myc, Transcription factor p64 |
| Calculated molecular weight | 48 aa, 8 kDa |
| Observed molecular weight | 62-65 kDa, 50 kDa |
| GenBank accession number | BC000917 |
| Gene symbol | MYC |
| Uniprot | P01106 |
| Gene ID (NCBI) | 4609 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
MYC contains one basic helix-loop-helix (bHLH) domain. This protein is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. It seems to activate the transcription of growth-related genes. It binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. This antibody is a rabbit polyclonal antibody raised against recombinant protein of human MYC.The 50kDa band recognized by antibody is the native form of MYC, while the other bands, between 60-70kDa, are the phosphorylated form of MYC [PMID: 12189186]
发表文章
| Species | Application | Title |
|---|---|---|
Oncogenesis SALL4 promotes gastric cancer progression through activating CD44 expression. | ||
Stem Cells Int Human Bone Marrow Mesenchymal Stem Cells Promote Gastric Cancer Growth via Regulating c-Myc. | ||
PLoS One Wogonin Has Multiple Anti-Cancer Effects by Regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 Pathways and Inducing Apoptosis in Human Lung Adenocarcinoma Cell Line A549. | ||
PLoS One Activation of Mesenchymal Stem Cells by Macrophages Prompts Human Gastric Cancer Growth through NF-κB Pathway. | ||
Mol Biol Rep PPARγ mediates the effects of WIN55,212-2, an synthetic cannabinoid, on the proliferation and apoptosis of the BEL-7402 hepatocarcinoma cells. | ||
Biochem Biophys Res Commun miR-612 suppresses the stemness of liver cancer via Wnt/β-catenin signaling. |
