• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

DM4

DM4 (Ravtansine)可用于制备抗体药物偶联物，是抗微管蛋白剂。 它抑制细胞分裂。

CAS号

796073-69-3

分子式

C38H54ClN3O10S

主要靶点

Others|Microtubule Associated

仅限科研使用

Cat No : CM05122

Print datasheet

Synonyms

美登素 DM4|Ravtansine

验证数据展示

  • CAS No.: 796073-69-3

    DM4
    CAS#: 796073-69-3

产品信息

DM4 can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division.

CAS号 796073-69-3
分子式 C38H54ClN3O10S
主要靶点 Others|Microtubule Associated
主要通路 细胞骨架|其他
分子量 780.37
纯度 98.15%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 美登素 DM4|Ravtansine

体外活性

DM4 is a cytotoxic maytansinoid drug and it is a structural analogue of maytansine. It also is a new thiol-containing and potent maytansinoid. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Which enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death[1].

溶解度

DMSO:99 mg/mL (126.86 mM),Sonification is recommended.

参考文献

1.Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2