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Mc-Val-Cit-PAB-Cl

Mc-Val-Cit-PAB-Cl 是一种可切割的 ADC 接头，可用于偶联 MMAE 和抗体以形成抗体-MC-vc-MMAE。

CAS号

1639351-92-0

分子式

C28H39ClN6O6

主要靶点

Others

仅限科研使用

Cat No : CM13664

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Synonyms

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  • CAS No.: 1639351-92-0

    Mc-Val-Cit-PAB-Cl
    CAS#: 1639351-92-0

产品信息

Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC50s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay). Mc-Val-Cit-PAB-Cl is a cleavable ADC linker.

CAS号 1639351-92-0
分子式 C28H39ClN6O6
主要靶点 Others
主要通路 其他
分子量 591.1
纯度 99.79%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

参考文献

1.Staben LR, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. ACS Med Chem Lett. 2017 Sep 5;8(10):1037-1041.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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