• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Meptazinol hydrochloride

Meptazinol hydrochloride (Meptazinol HCl) 是一种独特的中枢opioid 类镇痛剂，用作具有镇痛特性的麻醉拮抗剂。

CAS号

59263-76-2

分子式

C15H23NO·HCl

主要靶点

Opioid Receptor

仅限科研使用

Cat No : CM05357

Print datasheet

Synonyms

盐酸美普他酚|Meptazinol HCl

验证数据展示

  • CAS No.: 59263-76-2

    Meptazinol hydrochloride
    CAS#: 59263-76-2

产品信息

Meptazinol Hcl, a unique centrally opioid analgesic, is used as a narcotic antagonist with analgesic properties.

CAS号 59263-76-2
分子式 C15H23NO·HCl
主要靶点 Opioid Receptor
主要通路 G蛋白偶联受体|内分泌与激素|神经科学
分子量 269.81
纯度 99.83%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 盐酸美普他酚|Meptazinol HCl

体内活性

Naloxonazine treatment 24 hr earlier attenuates Meptazinol (10 mg/kg i.v.) analgesia in both the mouse writhing and rat tail-flick assays. Meptazinol administered with morphine does not reverse the respiratory depressant actions seen with morphine alone, distinguishing meptazinol from other mixed agonist/antagonists. [1] The absorption of Meptazinol (8 mg/kg i.v.) from nasal cavity to systemic circulation is rapid and complete in male Sprague-Dawley rats. The maximum observed concentration is achieved at 15 min after administration and the absolute bioavailability is 96.06%. The cerebrospinal fluid level of Meptazinol (8 mg/kg i.v.) attains a high concentration of 2.71 μg/mL and then is followed by an exponential decline. The concentration of intravenous Meptazinol (8 mg/kg i.v.) achieves a peak at 10 min followed by a steep decline in the cortex dialysate. [2] Inclusion of Meptazinol (2 mg/kg) reduces the total dose of anaesthetic required, allows a more rapid recovery and is associated with less movement in response to surgery in cystoscopy patients. The patients in the control group tends to hyperventilate, and has lower end-tidal CO2 tension, and also higher pulse rates during surgery than the Meptazinol group. [3] Meptazinol (25 mg/kg) evokes larger increases in nociceptive thresholds in the mouse than in the rat, whereas morphine induces large increases in both species. Antinociceptive responses to Meptazinol are consistently inhibited in animals pretreated with naloxone, whereas scopolamine attenuates the effects of meptazinol in some, particularly the mouse tail immersion test. [4] Meptazinol (2 mg/kg i.v.) greatly reduces the incidence of ventricular extrasystoles that resulted from acute coronary artery occlusion as well as ventricular fibrillation (VF) in rats. Meptazinol also reduces ventricular arrhythmias, including fibrillation, in conscious rats subjected to coronary artery occlusion. [5]

体外活性

Meptazinol inhibits a portion of 3H-labeled opiate and opioid peptide binding quite potently, with IC50 value under 1 nM. [1]

溶解度

DMSO:20.2 mg/mL (75 mM),H2O:27 mg/mL (100 mM)

参考文献

1.Spiegel K, et al. J Pharmacol Exp Ther, 1984, 228(2), 414-419.
2.Shi Z, et al. Life Sci, 2005, 77(20), 2574-2583.
3.Hargreaves J, et al. Anaesthesia, 1985, 40(5), 490-493.
4.Bill DJ, et al. Br J Pharmacol, 1983, 79(1), 191-199.
5.Fagbemi O, et al. Br J Pharmacol, 1983, 78(3), 455-460.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2