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Recombinant Mouse CD155/PVR protein (His Tag)

种属

Mouse

纯度

>95 %, SDS-PAGE

标签

His Tag

生物活性

EC50: 0.6-3 ng/mL

Cat no : Eg0903

Print datasheet

Synonyms

CD155/PVR, Pvr, CD155, poliovirus receptor, Tage4

验证数据展示

  • Purity of Recombinant Mouse CD155 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse CD155 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • Immobilized Mouse CD155 (His tag) at 1 μg/mL (100 μL/well) can bind Mouse TIGIT (hFc tag) with a linear range of 0.6-3 ng/mL.

    Immobilized Mouse CD155 (His tag) at 1 μg/mL (100 μL/well) can bind Mouse TIGIT (hFc tag) with a linear range of 0.6-3 ng/mL.

产品信息

纯度 >95 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Immobilized Mouse CD155 (His tag) at 1 μg/mL (100 μL/well) can bind Mouse TIGIT (hFc tag) with a linear range of 0.6-3 ng/mL.
来源 HEK293-derived Mouse CD155 protein Asp29-Leu348 (Accession# Q8K094) with His tag at the C-terminus.
基因ID 52118
蛋白编号 Q8K094
预测分子量 35.6 kDa
SDS-PAGE 48-65 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CD155, also known as poliovirus receptor (PVR) or nectin-like protein 5 (NECL-5), is a type I transmembrane glycoprotein which belongs to the nectin and nectin-like family of immunoglobulin superfamily receptors. Mature mouse CD155 consists of a 318 aa extracellular domain, a 24 aa transmembrane segment, and a 38 aa cytoplasmic tail. CD155 plays roles in cell motility, and natural killer and T cell-mediated immunity. It binds to two receptors of NK cells, CD96 and CD226, and accumulates at cell-cell contact sites, leading to the formation of mature immune synapses between NK cells and target cells.

参考文献:

1.Mendelsohn CL. et al. (1989). Cell. 56(5):855-865.
2.Pende D. et al. (2005). Mol Immunol. 42(4):463-469.
3.Fuchs A. et al. (2004). J Immunol. 172(7):3994-8.