Recombinant Mouse CD68 protein (His Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
His Tag
生物活性
未测试
验证数据展示
产品信息
纯度 | >90 %, SDS-PAGE |
内毒素 | <0.1 EU/μg protein, LAL method |
生物活性 | Not tested |
来源 | HEK293-derived Mouse CD68 protein Asp21-Ser291 (Accession# P31996-1) with a His tag at the C-terminus. |
基因ID | 12514 |
蛋白编号 | P31996-1 |
预测分子量 | 29.6 kDa |
SDS-PAGE | 60-90 kDa, reducing (R) conditions |
组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD68 is a 110 kDa transmembrane glycoprotein widely expressed in monocyte cell types, such as macrophages, microglia, and osteoclasts. It is located at the lysosome and plasma membrane and is essential in various physiological and pathological processes, including atherosclerosis formation, inflammation and auto-immunity, bone-resorbing promotion, and tumor progression. It participates in the cellular response to lipopolysaccharide/oxidized low-density lipoprotein particle stimulus and negative regulation of dendritic cell antigen processing and presentation.
参考文献:
1. C L Holness, et al. (1993) Blood. 81(6):1607-1613. 2. Maria C de Beer, et al. (2003) J Lipid Res. 44(4):674-685. 3. Li Song, et al. (2011) J Lipid Res. 52(8):1542-1550. 4. Jason W Ashley, et al. (2011) PLoS One. 6(10):e25838. 5. Gunnar Steinert, et al. (2014) Cancer Res. 74(6):1694-1704. 6. Giuseppe Troiano, et al. (2019) Oral Oncol. 93:66-75.