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Recombinant Mouse Tissue Factor protein (His Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

His Tag

生物活性

未测试

Cat no : Eg1102

Print datasheet

Synonyms

CD142, Coagulation factor III, F3, TF, TFA

验证数据展示

  • Purity of Recombinant Mouse Tissue Factor was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse Tissue Factor was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Mouse Tissue Factor protein Ala29-Glu251 (Accession# P20352) with a His tag at the C-terminus.
基因ID 14066
蛋白编号 P20352
预测分子量 26.5 kDa
SDS-PAGE 30-40 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Tissue factor (TF),also named coagulation factor III or F3, is a transmembrane protein that functions as a high-affinity receptor for factor (F)VII and FVIIa. The TF-FVIIa complex is the primary initiator of blood coagulation and plays an essential role in hemostasis. TF is expressed on perivascular cells and epithelial cells at organ and body surfaces where it forms a hemostatic barrier. TF also provides additional hemostatic protection to vital organs, such as the brain, lung, and heart. Under pathological conditions, TF can trigger both arterial and venous thrombosis.

参考文献:

1. Grover SP. et al. (2018). Arterioscler Thromb Vasc Biol. 38(4):709-725.
2. Mackman N. et al.(2007). Arterioscler Thromb Vasc Biol. 27:1687–1693.
3. Rao LV. et al. (2012). J Thromb Haemost. 10:2242–2253.
4. Witkowski M. et al. (2016). Trends Cardiovasc Med. 26(4):297-303.