• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

NCB-0846

NCB-0846 是一种具有口服活性的TNIK 抑制剂(IC50:21 nM)。

CAS号

1792999-26-8

分子式

C21H21N5O2

主要靶点

Wnt/beta-catenin|MAPK

仅限科研使用

Cat No : CM06691

Print datasheet

Synonyms

NCB 0846

验证数据展示

  • CAS No.: 1792999-26-8

    NCB-0846
    CAS#: 1792999-26-8

产品信息

NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).

CAS号 1792999-26-8
分子式 C21H21N5O2
主要靶点 Wnt/beta-catenin|MAPK
主要通路 MAPK信号通路|干细胞|细胞骨架
分子量 375.42
纯度 99.46%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 NCB 0846

靶点活性

TNIK:21 nM

体内活性

Sixty normal male and female volunteers between 18 and 40 years of age were recruited for a double-masked, placebo-controlled, crossover study in which each eye of each subject was dilated with 2.5% phenylephrine. After one hour, one eye was treated with 0.5% dapiprazole, and the contralateral eye was treated with placebo.

溶解度

DMSO:30 mg/mL

参考文献

1.Masuda M, et al. TNIK inhibition abrogates colorectal cancer stemness. Nat Commun. 2016 Aug 26;7:12586.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2