验证数据展示
产品信息
19550-1-AP targets Nicastrin in ELISA applications and shows reactivity with human samples.
| 经测试应用 | ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 | Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | nicastrin |
| 别名 | APH2, KIAA0253, NCSTN, nicastrin |
| 计算分子量 | 78 kDa |
| GenBank蛋白编号 | NM_015331 |
| 基因名称 | Nicastrin |
| Gene ID (NCBI) | 23385 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q92542 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
NCSTN, also named as KIAA0253, belongs to the nicastrin family. NCSTN is an essential subunit of the gamma-secretase complex. And it is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.