验证数据展示
产品信息
18737-1-AP targets ND4L in ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | ELISA Application Description |
| 经测试反应性 | human, mouse |
| 免疫原 | Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | NADH dehydrogenase, subunit 4L (complex I) |
| 别名 | MT ND4L, MTND4L, NADH dehydrogenase subunit 4L, NADH4L, ND4L |
| 计算分子量 | 11 kDa |
| GenBank蛋白编号 | P03901 |
| 基因名称 | ND4L |
| Gene ID (NCBI) | 4539 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
ND4L, also named as MTND4L and NADH4L, belongs to the complex I subunit 4L family. It is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Mutation of ND4L will cause Leber hereditary optic neuropathy (LHON) which is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction.