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  • Featured Product
  • KD/KO Validated

NEIL3 Polyclonal antibody, PBS Only

NEIL3 Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 11621-1-PBS

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Synonyms

验证数据展示

  • WB analysis of HEK-293 using 11621-1-AP (same clone as 11621-1-PBS)

    WB analysis of HEK-293 using 11621-1-AP (same clone as 11621-1-PBS)

    WB result of NEIL3 antibody (11621-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-NEIL3 transfected HEK-293 cells. This data was developed using the same antibody clone with 11621-1-PBS in a different storage buffer formulation.

  • WB analysis using 11621-1-AP (same clone as 11621-1-PBS)

    WB analysis using 11621-1-AP (same clone as 11621-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 11621-1-AP (NEIL3 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11621-1-PBS in a different storage buffer formulation.

产品信息

11621-1-PBS targets NEIL3 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Applications WB, Indirect ELISA Application Description
Tested Reactivity human, mouse
Immunogen NEIL3 fusion protein Ag2200 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name nei endonuclease VIII-like 3 (E. coli)
Synonyms
Calculated Molecular Weight 605 aa, 68 kDa
Observed Molecular Weight 62-68 kDa
GenBank Accession NumberBC025954
Gene Symbol NEIL3
Gene ID (NCBI) 55247
RRIDAB_2251229
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ8TAT5
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

NEIL3 belongs to the FPG family. It is a functional DNA glycosylase in vitro and in vivo. NEIL3 plays a role in repairing FapyG in vivo. (PMID:20185759) NEIL3 has AP lyase activity specific for single-stranded DNA.(PMID:19170771). NEIL3 is specifically expressed in brain areas where neurogenesis takes place during development and that its expression is tightly regulated both temporally and spatially (PMID:19426544). Studies have shown that NEIL3 is recruited to the DSB sites through its GRF zinc finger motifs and plays an important role in MMC/cisplatin-ICL repair by promoting the HR step in FA/BRCA pathway.(PMID: 36351389).