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验证数据展示

  • WB analysis of HEK-293 using 11621-1-AP (same clone as 11621-1-PBS)

    WB analysis of HEK-293 using 11621-1-AP (same clone as 11621-1-PBS)

    WB result of NEIL3 antibody (11621-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-NEIL3 transfected HEK-293 cells. This data was developed using the same antibody clone with 11621-1-PBS in a different storage buffer formulation.

  • WB analysis using 11621-1-AP (same clone as 11621-1-PBS)

    WB analysis using 11621-1-AP (same clone as 11621-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 11621-1-AP (NEIL3 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11621-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

NEIL3 Polyclonal antibody, PBS Only

NEIL3 Polyclonal Antibody for WB, Indirect ELISA
Cat No. 11621-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

11621-1-PBS targets NEIL3 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原 NEIL3 fusion protein Ag2200 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 nei endonuclease VIII-like 3 (E. coli)
别名
计算分子量 605 aa, 68 kDa
观测分子量 62-68 kDa
GenBank蛋白编号BC025954
基因名称 NEIL3
Gene ID (NCBI) 55247
RRIDAB_2251229
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ8TAT5
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

NEIL3 belongs to the FPG family. It is a functional DNA glycosylase in vitro and in vivo. NEIL3 plays a role in repairing FapyG in vivo. (PMID:20185759) NEIL3 has AP lyase activity specific for single-stranded DNA.(PMID:19170771). NEIL3 is specifically expressed in brain areas where neurogenesis takes place during development and that its expression is tightly regulated both temporally and spatially (PMID:19426544). Studies have shown that NEIL3 is recruited to the DSB sites through its GRF zinc finger motifs and plays an important role in MMC/cisplatin-ICL repair by promoting the HR step in FA/BRCA pathway.(PMID: 36351389).