验证数据展示
产品信息
83996-4-PBS targets NLRP7 in IF/ICC, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | IF/ICC, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 | NLRP7 fusion protein Ag27465 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | NLR family, pyrin domain containing 7 |
| 别名 | NOD12, NALP7, NACHT, LRR and PYD domains-containing protein 7, HYDM, CLR19.4 |
| 计算分子量 | 112 kDa, 115 kDa, 118 kDa |
| GenBank蛋白编号 | BC109125 |
| 基因名称 | NLRP7 |
| Gene ID (NCBI) | 199713 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purfication |
| UNIPROT ID | Q8WX94 |
| 储存缓冲液 | PBS only , pH 7.3 |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
NLRP7, also called NALP7 or PYPAF3, is a member of the NOD-like receptors (NLR), a family of proteins that plays a crucial role in the innate immune response. NLRP7 has been reported to emerge from NLRP2 gene. Similar to all inflammasomes, NLRP7 contributes to both pro- and an anti-inflammatory processes, depending on whether it functions in an inflammasome-dependent or independent pathway. The function of NLRP7 inflammasome has also been reported to depend on the master regulatory transcription factor protein that controls cellular inflammation, the NF-kB. In addition to its pro- and anti-inflammatory actions, NLRP7 plays a role in restricting intracellular bacterial replication and can also induce inflammasome assembly upon specific stimulation by FSL-1 (diacylated lipoprotein).