验证数据展示
经过测试的应用
| Positive WB detected in | transfected cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:200-1:1000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
发表文章中的应用
| WB | See 3 publications below |
产品信息
55113-1-AP targets NPR2 in WB, ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | WB, ELISA Application Description |
| 文献引用应用 | WB |
| 经测试反应性 | human, mouse |
| 文献引用反应性 | human, mouse |
| 免疫原 | Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) |
| 别名 | AMDM, ANP B, ANPR B, ANPRB, GC B, Guanylate cyclase B, GUC2B, GUCY2B, Natriuretic Peptide Receptor B, NPR2, NPRB |
| 计算分子量 | 117 kDa |
| 观测分子量 | 111 kDa, 117 kDa |
| GenBank蛋白编号 | NM_003995 |
| 基因名称 | NPR2 |
| Gene ID (NCBI) | 4882 |
| RRID | AB_2881270 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P20594 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Aliquoting is unnecessary for -20oC storage. |
背景介绍
NPR2, also named as ANPRB, GC-B, NPR-B, ANPR-B and ANP-B, belongs to the adenylyl cyclase class-4/guanylyl cyclase family. It is a receptor for the C-type natriuretic peptide NPPC/CNP hormone. NRP2 has guanylate cyclase activity upon binding of its ligand. It may play a role in the regulation of skeletal growth. NPR2 is the primary receptor for C type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Defects in NPR2 are the cause of acromesomelic dysplasia Maroteaux type (AMDM). The antibody is specific to NPR2.
发表文章
| Species | Application | Title |
|---|---|---|
Int J Mol Sci Evidence for Angiotensin II as a Naturally Existing Suppressor for the Guanylyl Cyclase A Receptor and Cyclic GMP Generation | ||
Proc Natl Acad Sci U S A Discovery of another mechanism for the inhibition of particulate guanylyl cyclases by the natriuretic peptide clearance receptor | ||
bioRxiv EVIDENCE FOR ANGIOTENSIN II AS A NATURALLY EXISTING SUPPRESSOR FOR THE NATRIURETIC PEPTIDE SYSTEM |