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  • Featured Product
  • KD/KO Validated

NR1H2 Monoclonal antibody, PBS Only

NR1H2 Monoclonal Antibody for WB, ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human, pig

Applications

WB, ELISA

Conjugate

Unconjugated

CloneNo.

1E12B10

Cat No : 60345-1-PBS

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Synonyms

Liver X receptor beta, LXR b, LXRB, NER, NER I, NR1H2, Nuclear receptor NER, Oxysterols receptor LXR beta, RIP15, UNR

验证数据展示

  • WB analysis of human liver using 60345-1-Ig (same clone as 60345-1-PBS)

    WB analysis of human liver using 60345-1-Ig (same clone as 60345-1-PBS)

    human liver tissue were subjected to SDS PAGE followed by western blot with 60345-1-Ig (NR1H2 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60345-1-PBS in a different storage buffer formulation.

产品信息

60345-1-PBS targets NR1H2 in WB, ELISA applications and shows reactivity with human, pig samples.

Tested Applications WB, ELISA Application Description
Tested Reactivity human, pig
Immunogen NR1H2 fusion protein Ag5635 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name nuclear receptor subfamily 1, group H, member 2
Synonyms Liver X receptor beta, LXR b, LXRB, NER, NER I, NR1H2, Nuclear receptor NER, Oxysterols receptor LXR beta, RIP15, UNR
Calculated Molecular Weight 51 kDa
Observed Molecular Weight 51 kDa
GenBank Accession NumberBC047750
Gene Symbol NR1H2
Gene ID (NCBI) 7376
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP55055
Storage Buffer PBS only
Storage ConditionsStore at -80°C.

背景介绍

NR1H2, also known as LXRB, is a liver X receptors, which form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. It preferentially bind to double-stranded oligonucleotide direct repeats, which have the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). It involves in the regulation of cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.