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  • Featured Product
  • KD/KO Validated

NR2F6 Monoclonal antibody, PBS Only

NR2F6 Monoclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human, rat

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

2H2B8

Cat no : 60117-2-PBS

Print datasheet

Synonyms

V erbA related protein 2, ERBAL2, EAR-2, EAR2, EAR 2

验证数据展示

  • WB analysis of HeLa using 60117-2-Ig (same clone as 60117-2-PBS)

    WB analysis of HeLa using 60117-2-Ig (same clone as 60117-2-PBS)

    WB result of NR2F6 antibody (60117-2-Ig, 1:1000) with si-Control and si-NR2F6 transfected HeLa cells. This data was developed using the same antibody clone with 60117-2-PBS in a different storage buffer formulation.

  • IHC staining of human ovary tumor using 60117-2-Ig (same clone as 60117-2-PBS)

    IHC staining of human ovary tumor using 60117-2-Ig (same clone as 60117-2-PBS)

    Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 60117-2-Ig (NR2F6 antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 60117-2-PBS in a different storage buffer formulation.

  • WB analysis using 60117-2-Ig (same clone as 60117-2-PBS)

    WB analysis using 60117-2-Ig (same clone as 60117-2-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 60117-2-Ig (NR2F6 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60117-2-PBS in a different storage buffer formulation.

产品信息

60117-2-PBS targets NR2F6 in WB, IHC, Indirect ELISA applications and shows reactivity with human, rat samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity human, rat
Immunogen NR2F6 fusion protein Ag7614 种属同源性预测
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Full Name nuclear receptor subfamily 2, group F, member 6
Synonyms V erbA related protein 2, ERBAL2, EAR-2, EAR2, EAR 2
Calculated Molecular Weight 43 kDa
Observed Molecular Weight 43 kDa
GenBank Accession NumberBC002669
Gene Symbol NR2F6
Gene ID (NCBI) 2063
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP10588
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

NR2F6 belongs to NR2F subfamily members, which have their roles in the regulation of neurogenesis, organogenesis, and cellular differentiation during embryonic development (PMID:15875024). NR2F6 acts as transcription factor by binding to a TGACCT direct-repeat motif and has been established in controlling facets of central nervous system (CNS) (PMID: 12690040). It is a nuclear attenuator that directly interferes with DNA binding of NF-AT and, subsequently, transcriptional activity of the NF-AT-dependent IL-17 expression. Otherwise, NR2F6 negatively interfered with transcriptional cytokine responses and acted as a barrier against autoimmunity (PMID:18701084).