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NUMB Monoclonal antibody
NUMB Monoclonal Antibody for ELISA
Host / Isotype
Mouse / IgG2a
Reactivity
human, mouse, rat
Applications
ELISA and More (3)
Conjugate
Unconjugated
CloneNo.
2G12B7
验证数据展示
产品信息
60137-1-Ig targets NUMB in WB, IF, CoIP, ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Applications | ELISA Application Description |
| Cited Applications | WB, IF, CoIP |
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human, mouse, rat |
| Immunogen | peptide 种属同源性预测 |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | numb homolog (Drosophila) |
| Synonyms | h-Numb, h Numb, C14orf41, 2G12B7 |
| Calculated Molecular Weight | 71 kDa |
| Observed Molecular Weight | 66-72 kDa |
| GenBank Accession Number | BC068476 |
| Gene Symbol | NUMB |
| Gene ID (NCBI) | 8650 |
| RRID | AB_10598775 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P49757 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
NUMB, also named as S171, plays a role in the determination of cell fates during development. It is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. The degradation of NUMB is induced in a proteasome-dependent manner by MDM2. Four transcript variants encoding different isoforms have been found for this gene. The antibody can bind to all these four isoforms P65, P66, P71 and P72, can't recognize the NUMBL.
发表文章
| Species | Application | Title |
|---|---|---|
Sci Rep Hepatic stem cell Numb gene is a potential target of Huang Qi Decoction against cholestatic liver fibrosis.
| ||
Neurosci Lett Numb deficiency causes impaired trafficking of mGlu5 in neurons and autistic-like behaviors.
| ||
Mol Biol Rep Different roles of Numb-p72 and Numb-p65 on the trafficking of metabotropic glutamate receptor 5. | ||
Stem Cell Res Ther BM-MSCs overexpressing the Numb enhance the therapeutic effect on cholestatic liver fibrosis by inhibiting the ductular reaction | ||
Cell Rep Stabilizing vimentin phosphorylation inhibits stem-like cell properties and metastasis of hybrid epithelial/mesenchymal carcinomas |