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Naratriptan hydrochloride

Naratriptan hydrochloride (GR-85548A hydrochloride) 是一种5-HT1受体激动剂，有抗偏头疼特性。它还可以通过刺激三叉神经系统感觉神经末梢上的 5-HT1D/1B 受体来发挥其作用，从而减少促炎神经肽的释放。

CAS号

143388-64-1

分子式

C17H25N3O2S·HCl

主要靶点

5-HT Receptor

仅限科研使用

Cat No : CM02338

Print datasheet

Synonyms

GR-85548A hydrochloride|Naratriptan HCl|Naramig|Amerge|盐酸那拉曲坦

验证数据展示

  • CAS No.: 143388-64-1

    Naratriptan hydrochloride
    CAS#: 143388-64-1

产品信息

Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation of these 5-HT1D/B receptors located on intracranial blood vessels leads to vasoconstriction and provides relief of migraine headaches. Naratriptan hydrochloride may also exerts its effect by stimulation of 5-HT1D/1B receptors on sensory nerve endings in the trigeminal system thereby decreasing the release of pro-inflammatory neuropeptides.

CAS号 143388-64-1
分子式 C17H25N3O2S·HCl
主要靶点 5-HT Receptor
主要通路 神经科学|G蛋白偶联受体
分子量 371.93
纯度 99.89%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 GR-85548A hydrochloride|Naratriptan HCl|Naramig|Amerge|盐酸那拉曲坦

溶解度

Ethanol:<1 mg/mL,DMSO:69 mg/mL (185.5 mM),H2O:20 mg/mL (53.8 mM)

参考文献

1.Sattar M, Hadgraft J, Lane ME.Int J Pharm. 2015 Sep 30;493(1-2):146-51.
2.Ephross SA, Sinclair SM. Headache. 2014 Jul-Aug;54(7):1158-72.

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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