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Nemorubicin

Nemorubicin (PNU 152243) 是一种 Doxorubicin 衍生物，具有抗肿瘤活性。它需要完整的核苷酸切除修复系统才能发挥活性。它对多药耐药表型的多种肿瘤细胞系具有细胞毒性。

CAS号

108852-90-0

分子式

C32H37NO13

主要靶点

Others

仅限科研使用

Cat No : CM07326

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Synonyms

PNU-152243A|Methoxymorpholinyldoxorubicin|奈莫柔比星|PNU 152243

验证数据展示

  • CAS No.: 108852-90-0

    Nemorubicin
    CAS#: 108852-90-0

产品信息

Nemorubicin is a doxorubicin derivative that differs significantly from its parent drug in terms of spectrum of antitumor activity, metabolism and toxicity profile. The drug is active on tumors resistant to alkylating agents, topoisomerase II inhibitors and platinum derivatives.

CAS号 108852-90-0
分子式 C32H37NO13
主要靶点 Others
主要通路 其他
分子量 643.64
纯度 97.79%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 PNU-152243A|Methoxymorpholinyldoxorubicin|奈莫柔比星|PNU 152243

溶解度

DMSO:45 mg/mL (69.91 mM)

参考文献

1.Quintieri L, et al. In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: a comparison with human liver microsomes. Biochem Pharmacol. 2008 Sep 15;76(6):784-95. 2.Lu H, et al. Potentiation of methoxymorpholinyl doxorubicin antitumor activity by P450 3A4 gene transfer. Cancer Gene Ther. 2009 May;16(5):393-404.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2