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NoxA1ds acetate(1435893-78-9 free base)

NoxA1ds acetate(1435893-78-9 free base) 是一种有效的选择性 NADPH 氧化酶 1 (NOX1) 抑制剂 (IC50 : 20 nM)。对 NOX1 的选择性优于对 NOX2、NOX4、NOX5 和黄嘌呤氧化酶的选择性。它抑制 HT-29 人结肠癌细胞中 NOX1 衍生的 O2 产生。在体外缺氧条件下减弱 VEGF 诱导的人肺动脉内皮细胞迁移。

CAS号

TP1886L1

分子式

C52H92N14O17

主要靶点

NADPH-oxidase

仅限科研使用

Cat No : CM07920

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Synonyms

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  • CAS No.: TP1886L1

    NoxA1ds acetate(1435893-78-9 free base)
    CAS#: TP1886L1

产品信息

NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.

CAS号 TP1886L1
分子式 C52H92N14O17
主要靶点 NADPH-oxidase
主要通路 免疫与炎症
分子量 1185.35
纯度 96.92%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

NOX1:20 nM

溶解度

H2O:10 mM,DMSO:Insoluble

参考文献

1.Ranayhossaini et al (2013) Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration. J.Biol.Chem. 288 36437 PMID:

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