• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

OSMI-1

OSMI-1 是O-GlcNAc 转移酶的选择性抑制剂，IC50值为 2.7 μM。它抑制哺乳动物细胞系中的蛋白 O-连接的 N-乙酰氨基葡萄糖，而没有定性地改变细胞表面 N-或 O-连接的聚糖。

CAS号

1681056-61-0

分子式

C28H25N3O6S2

主要靶点

Others|Acyltransferase

仅限科研使用

Cat No : CM05352

Print datasheet

Synonyms

验证数据展示

  • CAS No.: 1681056-61-0

    OSMI-1
    CAS#: 1681056-61-0

产品信息

OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor (IC50: 2.7 μM).

CAS号 1681056-61-0
分子式 C28H25N3O6S2
主要靶点 Others|Acyltransferase
主要通路 代谢|其他
分子量 563.64
纯度 99.83%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

靶点活性

O-GlcNAc transferase (OGT):2.7 μM

体内活性

The zebrafish model is used to investigate OSM1-1 acute toxicity in vivo. The LC50 of OSM1-1 is 0.031?mg/mL (56?μM, 12?h) and 0.025?mg/mL (45?μM, 24?h) in zebrafish model[2].

体外活性

OSMI-1 inhibits OGT activity in cells. OSMI-1 (50 μM; 24 hours; CHO cells) treatment reduces the viability by about 50% after 24 hours. OSMI-1 (10-100 μM; 24 hours; CHO cells) treatment decreases global O-linked N-acetylglucosamine (O-GlcNAcylation) a dose-dependent manner [1].

溶解度

DMSO:83.33 mg/mL (147.84 mM),Sonification is recommended.

参考文献

1.Ortiz-Meoz RF, et al. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 2015 Jun 19;10(6):1392-7.
2.Liu Y, et al. Discovery of a Low Toxicity O-GlcNAc Transferase (OGT) Inhibitor by Structure-based Virtual Screening of Natural Products. Sci Rep. 2017 Sep 26;7(1):12334.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2