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OSMR Polyclonal antibody

OSMR Polyclonal Antibody for WB, ELISA
Cat No. 10982-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, monkey and More (1)

应用

WB, ELISA and More (2)

Oncostatin-M-specific receptor subunit beta, Interleukin-31 receptor subunit beta, IL-31R-beta, IL-31RB, IL-31R subunit beta

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -


经过测试的应用

Positive WB detected inHeLa cells, A375 cells, HEK-293T cells, Raji cells, HepG2 cells

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:1000-1:4000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

10982-1-AP targets OSMR in WB, IHC, IF, ELISA applications and shows reactivity with human, monkey samples.

经测试应用 WB, ELISA Application Description
文献引用应用WB, IHC, IF
经测试反应性 human, monkey
文献引用反应性human, mouse
免疫原 OSMR fusion protein Ag1426 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 oncostatin M receptor
别名 Oncostatin-M-specific receptor subunit beta, Interleukin-31 receptor subunit beta, IL-31R-beta, IL-31RB, IL-31R subunit beta
计算分子量 110 kDa
观测分子量 110 kDa
GenBank蛋白编号BC010943
基因名称 OSMR
Gene ID (NCBI) 9180
RRIDAB_2156583
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ99650
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Oncostatin M (OSM) is a member of interleukin-6 family cytokines that modulates proliferation and differentiation in numerous cells (PMID: 22982441). OSM signals via a receptor complex comprising gp130 and the OSMR (also refered to as OSMRβ) (PMID: 8999038). OSMR is a single-pass membrane protein that belongs to the type I cytokine receptor family. OSMR mRNA is expressed at relatively high levels in all neural cells and fibroblast, epithelial, and various tumor cell lines (PMID: 8999038). It has also been shown that OSMR associates with IL31RA to form the heterodimeric IL31 receptor (PMID: 15184896). A 70 kDa soluble form can be detected by western blot (PMID: 17028186).

实验方案

Product Specific Protocols
WB protocol for OSMR antibody 10982-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
human,mouseWB

Cell Stem Cell

Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling.

Authors - Kubin Thomas T
mouse,humanIF

Sci Adv

Repression of Osmr and Fgfr1 by miR-1/133a prevents cardiomyocyte dedifferentiation and cell cycle entry in the adult heart.

Authors - Melissa Valussi
  • KO Validated
humanIHC

Cell Rep

Deep spatial proteomics reveals region-specific features of severe COVID-19-related pulmonary injury

Authors - Yiheng Mao
IF

Br J Dermatol

CD11b+ cells markedly express the itch cytokine interleukin-31 in polymorphic light eruption.

Authors - V Patra
humanWB

Aging (Albany NY)

Elevated lymphocyte specific protein 1 expression is involved in the regulation of leukocyte migration and immunosuppressive microenvironment in glioblastoma.

Authors - Jing-Yuan Cao
mouseWB

Stem Cell Res Ther

Oncostatin M receptor regulates osteoblast differentiation via extracellular signal-regulated kinase/autophagy signaling.

Authors - Jie Zhou
  • KD Validated
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