验证数据展示
经过测试的应用
Positive WB detected in | HeLa cells, A375 cells, HEK-293T cells, Raji cells, HepG2 cells |
推荐稀释比
应用 | 推荐稀释比 |
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Western Blot (WB) | WB : 1:1000-1:4000 |
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
产品信息
10982-1-AP targets OSMR in WB, IHC, IF, ELISA applications and shows reactivity with human, monkey samples.
经测试应用 | WB, ELISA Application Description |
文献引用应用 | WB, IHC, IF |
经测试反应性 | human, monkey |
文献引用反应性 | human, mouse |
免疫原 | OSMR fusion protein Ag1426 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | oncostatin M receptor |
别名 | Oncostatin-M-specific receptor subunit beta, Interleukin-31 receptor subunit beta, IL-31R-beta, IL-31RB, IL-31R subunit beta |
计算分子量 | 110 kDa |
观测分子量 | 110 kDa |
GenBank蛋白编号 | BC010943 |
基因名称 | OSMR |
Gene ID (NCBI) | 9180 |
RRID | AB_2156583 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Antigen affinity purification |
UNIPROT ID | Q99650 |
储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Oncostatin M (OSM) is a member of interleukin-6 family cytokines that modulates proliferation and differentiation in numerous cells (PMID: 22982441). OSM signals via a receptor complex comprising gp130 and the OSMR (also refered to as OSMRβ) (PMID: 8999038). OSMR is a single-pass membrane protein that belongs to the type I cytokine receptor family. OSMR mRNA is expressed at relatively high levels in all neural cells and fibroblast, epithelial, and various tumor cell lines (PMID: 8999038). It has also been shown that OSMR associates with IL31RA to form the heterodimeric IL31 receptor (PMID: 15184896). A 70 kDa soluble form can be detected by western blot (PMID: 17028186).
实验方案
Product Specific Protocols | |
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WB protocol for OSMR antibody 10982-1-AP | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |
发表文章
Species | Application | Title |
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Cell Stem Cell Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling. | ||
Sci Adv Repression of Osmr and Fgfr1 by miR-1/133a prevents cardiomyocyte dedifferentiation and cell cycle entry in the adult heart.
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Cell Rep Deep spatial proteomics reveals region-specific features of severe COVID-19-related pulmonary injury | ||
Br J Dermatol CD11b+ cells markedly express the itch cytokine interleukin-31 in polymorphic light eruption. | ||
Aging (Albany NY) Elevated lymphocyte specific protein 1 expression is involved in the regulation of leukocyte migration and immunosuppressive microenvironment in glioblastoma. | ||
Stem Cell Res Ther Oncostatin M receptor regulates osteoblast differentiation via extracellular signal-regulated kinase/autophagy signaling.
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