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OSTbeta / SLC51B Polyclonal antibody

OSTbeta / SLC51B Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IHC, ELISA

Conjugate

Unconjugated

Cat no : 21248-1-AP

Print datasheet

Synonyms

OST beta, OSTB, OSTbeta, SLC51B

验证数据展示

  • IHC staining of human small intestine using 21248-1-AP

    IHC staining of human small intestine using 21248-1-AP

    Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 21248-1-AP (OSTbeta antibody) at dilution of 1:200 (under 10x lens).

  • IHC staining of human small intestine using 21248-1-AP

    IHC staining of human small intestine using 21248-1-AP

    Immunohistochemical analysis of paraffin-embedded human small intestine tissue slide using 21248-1-AP (OSTbeta antibody) at dilution of 1:200 (under 40x lens).

经过测试的应用

Positive IHC detected inhuman small intestine tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

21248-1-AP targets OSTbeta / SLC51B in IHC, ELISA applications and shows reactivity with human samples.

Tested Applications IHC, ELISA Application Description
Tested Reactivity human
Immunogen OSTbeta / SLC51B fusion protein Ag15751 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name organic solute transporter beta
Synonyms OST beta, OSTB, OSTbeta, SLC51B
Calculated Molecular Weight 128 aa, 14 kDa
GenBank Accession NumberBC103842
Gene Symbol SLC51B
Gene ID (NCBI) 123264
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ86UW2
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

Organic solute transporter alpha-beta (Ostα-Ostβ) is a heteromeric transporter that has been localized to the basolateral membrane of epithelial cells of the small intestine, kidney and liver, and appears to be essential for bile acid homeostasis. The transporter is composed of a predicted 340-amino acid, 7-transmembrane domain protein (Ostα) and a putative 128-amino acid, single-transmembrane domain polypeptide (Ostβ). Ostα-Ostβ transports bile acids by a facilitated diffusion mechanism; therefore, Ostα-Ostβ can mediate cellular efflux or uptake depending on the substrate's electrochemical gradient. It's reported that Ostα-Ostβ is not only essential for bile acid, but also vital for sterol disposition and enterohepatic circulation(PMID: 21691099).

实验方案

Product Specific Protocols
IHC protocol for OSTbeta / SLC51B antibody 21248-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols