• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Oclacitinib maleate

Oclacitinib maleate (PF-03394197 maleate) 是一种新型JAK 抑制剂，有效抑制JAK1，IC50为 10 nM。

CAS号

1640292-55-2

分子式

C15H23N5O2S·C4H4O4

主要靶点

Tyrosine Kinases|JAK

仅限科研使用

Cat No : CM04902

Print datasheet

Synonyms

PF-03394197|PF-03394197 maleate|奥拉替尼马来酸盐

验证数据展示

  • CAS No.: 1640292-55-2

    Oclacitinib maleate
    CAS#: 1640292-55-2

产品信息

Oclacitinib is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM, which did not inhibit a panel of 38 non-JAK kinases.

CAS号 1640292-55-2
分子式 C15H23N5O2S·C4H4O4
主要靶点 Tyrosine Kinases|JAK
主要通路 JAK/STAT信号通路|干细胞|表观遗传|蛋白酪氨酸激酶|血管生成
分子量 453.51
纯度 99.17%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 PF-03394197|PF-03394197 maleate|奥拉替尼马来酸盐

靶点活性

JAK1-dependent:36 to 249 nM|JAK family members:10 to 99 nM

体内活性

PF-03394197 administered orally at a dose of 0.4–0.6 mg/kg twice daily is safe and efficacious in controlling the pruritus associated with allergic dermatitis. PF-03394197 provides itch relief within 24 h that persistes through the treatment period, with over 70% of the treated dogs achieving a >50% reduction in pruritus by day 7[2].

体外活性

PF-03394197 inhibits JAK family members by 50% at concentrations ranging from 10 to 99 nM and does not inhibit a panel of 38 non-JAK kinases. PF-03394197 is most potent at inhibiting JAK1. PF-03394197 also inhibits the function of JAK1-dependent cytokines involved in allergy and inflammation as well as pruritus. PF-03394197 has minimal effects on cytokines which does not activate the JAK1 enzyme in cells[1].

溶解度

DMSO:83 mg/mL (183 mM),Ethanol:83 mg/mL (183 mM),H2O:15 mg/mL (33.1 mM)

参考文献

1.Gonzales AJ, et al. J Vet Pharmacol Ther. 2014, 37(4):317-324.
2.Cosgrove SB, et al. Vet Dermatol. 2013, 24(5):479-e114.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2