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Omecamtiv mecarbil

Omecamtiv mecarbil (CK-1827452) 是一种心脏特异性的肌球蛋白激活剂，用于研究心脏相关疾病。

CAS号

873697-71-3

分子式

C20H24FN5O3

主要靶点

ATPase|Myosin

仅限科研使用

Cat No : CM05241

Print datasheet

Synonyms

CK-1827452

验证数据展示

  • CAS No.: 873697-71-3

    Omecamtiv mecarbil
    CAS#: 873697-71-3

产品信息

Omecamtiv Mecarbil has been used in trials studying the treatment and basic science of Heart Failure, Echocardiogram, Pharmacokinetics, Chronic Heart Failure, and History of Chronic Heart Failure, among others.

CAS号 873697-71-3
分子式 C20H24FN5O3
主要靶点 ATPase|Myosin
主要通路 细胞骨架|离子通道
分子量 401.43
纯度 99.62%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 CK-1827452

体内活性

在离体心肌细胞中,Omecamtiv mecarbil可以增加肌细胞收缩力,克服肌球蛋白抑制剂BDM而不增加钙瞬变或抑制PDE通路。在体外,Omecamtiv mecarbil通过增加肌球蛋白ATPase速率选择性地激活心肌肌球蛋白。

体外活性

Omecamtiv mecarbil会导致一些血流动力学参数（包括心率,平均左心房压力和左心室舒张末期压力）的下降.OOmecamtiv mecarbil在左心室肥大的清醒的狗体内,对血流动力学参数产生相似且无统计学差异的影响.在有心肌梗死（MI-sHF）的有意识的狗中,Omecamtiv mecarbil导致壁增厚（25％）,每搏输出量（44％）,心输出量（22％）和左心室（LV）收缩射血时间显著增加（26％）.

溶解度

DMSO:74 mg/mL (184.3 mM),Ethanol:6 mg/mL (14.94 mM)

参考文献

1.Anderson RL, et al. Mol Bio Cell, 2005, 16 (Abstract #1728).
2.Shen YT, et al. Circ Heart Fail. 2010, 3(4), 522-577.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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