• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

PACAP (1-38), human, ovine, rat

PACAP 1-38 is a potent PACAP receptor agonist with IC50s of 4 nM, 2 nM, and 1 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 respectively.

CAS号

137061-48-4

分子式

N/A

主要靶点

cAMP

仅限科研使用

Cat No : CM03262

Print datasheet

Synonyms

H-HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-GLY-LYS-ARG-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2

验证数据展示

  • CAS No.: 137061-48-4

    PACAP (1-38), human, ovine, rat
    CAS#: 137061-48-4

  • PACAP (1-38), human, ovine, rat<br/>CAS#: 137061-48-4

    PACAP (1-38), human, ovine, rat
    CAS#: 137061-48-4

产品信息

PACAP 1-38 has potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. It is a pleiotropic neuropeptide, exhibiting a variety of biologic actions, including activities as a neurotransmitter, neuromodulator, neurotrophic factor, as well as an immunomodulator, in immune cells through its effect on MAPK signaling and modulation of activation of NFκB. PACAP 1-38 dramatically prevents injury of cultured renal proximal tubule cells caused by myeloma light chains through suppression of proinflammatory cytokines production, by inhibiting p38 MAPK and translocation of NFκB via both PAC1 and VPAC1 receptors. PACAP38 inhibits myeloma cell growth directly and may also indirectly by suppressing production of the growth factor, IL-6, from bone marrow stromal cells, that is stimulated by adhesion of myeloma cells. PACAP38 suppressed release of both IL-6 and TNFα dose dependently.

CAS号 137061-48-4
分子式 N/A
主要靶点 cAMP
主要通路 GPCR/G Protein
分子量 0.0
MDL NO MFCD00081800
Pubchem ID
纯度 98.62%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
粉末 -20°C 3年
液体 -80°C 1年
运输条件 Shipped in cold pack
别名 H-HIS-SER-ASP-GLY-ILE-PHE-THR-ASP-SER-TYR-SER-ARG-TYR-ARG-LYS-GLN-MET-ALA-VAL-LYS-LYS-TYR-LEU-ALA-ALA-VAL-LEU-GLY-LYS-ARG-TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2

靶点

TargetActivity
PACAP receptorIC50=4nM
PACAP type II receptorIC50=2nM
PACAP type III receptorIC50=1nM

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2