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Host
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Species Reactivity
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Species Reactivity
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Conjugate
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Conjugate
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Conjugate
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验证数据展示

  • WB analysis of MCF-7 using 85167-1-RR (same clone as 85167-1-PBS)

    WB analysis of MCF-7 using 85167-1-RR (same clone as 85167-1-PBS)

    MCF-7 cells were subjected to SDS PAGE followed by western blot with 85167-1-RR (PARL antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85167-1-PBS in a different storage buffer formulation.

  • WB analysis using 85167-1-RR (same clone as 85167-1-PBS)

    WB analysis using 85167-1-RR (same clone as 85167-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 85167-1-RR (PARL antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85167-1-PBS in a different storage buffer formulation.

PARL Recombinant antibody, PBS Only

PARL Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA
Cat No. 85167-1-PBS

产品说明书

CloneNo. 242171C12

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, Indirect ELISA

别名

PRO2207, Presenilin-associated rhomboid-like protein, mitochondrial, P-beta, Pbeta, EC:3.4.21.105

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

85167-1-PBS targets PARL in WB, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human
免疫原 PARL fusion protein Ag24789 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 presenilin associated, rhomboid-like
别名 PRO2207, Presenilin-associated rhomboid-like protein, mitochondrial, P-beta, Pbeta, EC:3.4.21.105
计算分子量 42 kDa
观测分子量45 kDa
GenBank蛋白编号BC014058
基因名称 PARL
Gene ID (NCBI) 55486
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDQ9H300
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PARL (Presenilin associated rhomboid like), is a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. PARL has 2 isoforms produced by alternative splicing with the molecular mass of 42 kDa and 37 kDa. PARL regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of PARL may result in the release of a small peptide, P-beta, which may transit to the nucleus. The self-regulated cleavage of PARL at positions 52-53 (α-site) and 77--78 (β-site) produce two cleaved forms of PARL named MAMP and PACT with the molecular mass of 36 kDa and 33 kDa respectively (PMID: 14732705, 28178523).