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PARP10-IN-2

PARP10-IN-2 是一种有效的单-ADP-核糖基转移酶 PARP10 抑制剂，对人 PARP10 的 IC50 值为 3.64 μM。PARP10-IN-2 对 PARP2 和 PARP15也具有抑制作用， IC50 分别为 27 μM 和 11 μM。

CAS号

1042780-52-8

分子式

C14H10N2O2

主要靶点

PARP

仅限科研使用

Cat No : CM15256

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Synonyms

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  • CAS No.: 1042780-52-8

    PARP10-IN-2
    CAS#: 1042780-52-8

产品信息

PARP10-IN-2 is a potent inhibitor of PARP10, a mono-ADP-ribosyltransferase, with an IC50 value of 3.64 μM for human PARP10.PARP10-IN-2 also inhibited PARP2 and PARP15, with IC50 values of 27 μM and 11 μM, respectively.

CAS号 1042780-52-8
分子式 C14H10N2O2
主要靶点 PARP
主要通路 DNA损伤和修复|表观遗传
分子量 238.24
纯度 99.68%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
别名

靶点活性

human PARP15:11 μM|human PARP10:3.64 μM|human PARP2:27 μM

体外活性

PARP10-IN-2 (Compound 10) has an IC50 of 1-2 μM by clonogenic assay (CFA) in HeLa-PARP10 cells.[1]

溶解度

DMSO:225.0 mg/mL (944.4 mM),Sonification is recommended.

参考文献

1.Korn P, et al. Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. ChemistryOpen. 2021;10(10):939-948.

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