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PARP10-IN-3

PARP10-IN-3 是一种有效且具有选择性的单-ADP-核糖基转移酶 PARP10 抑制剂，对人 PARP10 具有抑制作用（ IC50 ：480 nM）。PARP10-IN-3 对人 PARP2 和 人 PARP15也具有抑制作用， IC50 值都是 1.7 μM。

CAS号

2225800-19-9

分子式

C14H12N2O3

主要靶点

PARP

仅限科研使用

Cat No : CM07304

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Synonyms

验证数据展示

  • CAS No.: 2225800-19-9

    PARP10-IN-3
    CAS#: 2225800-19-9

产品信息

PARP10-IN-3 is a potent and selective mono-Adp-ribotransferase PARP10 inhibitor that inhibits human PARP10 (IC50:480 nM). PARP10-IN-3 also inhibited human PARP2 and human PARP15 with IC50 values of 1.7 μM.

CAS号 2225800-19-9
分子式 C14H12N2O3
主要靶点 PARP
主要通路 DNA损伤和修复|表观遗传
分子量 256.26
纯度 99.54%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
别名

靶点活性

PARP16(human):>10 μM|TNKS2(human):6.5 μM|PARP3(human):>100 μM|PARP14(human):41 μM|PARP15(human):1.7 μM|PARP4(human):7 μM|PARP10(human):480 nM|TNKS1(human):21 μM|PARP2(human):1.7 μM|PARP12(human):>10 μM|PARP1(human):>100 μM

体外活性

PARP10-IN-3 exhibits an IC50 of 1-2 μM in HeLa-PARP10 cells as determined by colony formation assay (CFA).[1]

溶解度

DMSO:9 mg/mL (35.12 mM)

参考文献

1.Korn P, et al. Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. ChemistryOpen. 2021;10(10):939-948.

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