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Conjugate
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PAX3 Polyclonal antibody, PBS Only

PAX3 Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 51036-2-PBS

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Synonyms

验证数据展示

  • IHC staining of rat brain using 51036-2-AP (same clone as 51036-2-PBS)

    IHC staining of rat brain using 51036-2-AP (same clone as 51036-2-PBS)

    Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 51036-2-AP (PAX3 antibody) at dilution of 1:800 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 51036-2-PBS in a different storage buffer formulation.

  • IHC staining of rat brain using 51036-2-AP (same clone as 51036-2-PBS)

    IHC staining of rat brain using 51036-2-AP (same clone as 51036-2-PBS)

    Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 51036-2-AP (PAX3 antibody) at dilution of 1:800 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 51036-2-PBS in a different storage buffer formulation.

  • WB analysis of mouse skin using 51036-2-AP (same clone as 51036-2-PBS)

    WB analysis of mouse skin using 51036-2-AP (same clone as 51036-2-PBS)

    mouse skin tissue were subjected to SDS PAGE followed by western blot with 51036-2-AP (PAX3 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 51036-2-PBS in a different storage buffer formulation.

产品信息

51036-2-PBS targets PAX3 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

Tested Applications WB, IHC, Indirect ELISA Application Description
Tested Reactivity human, mouse
Immunogen PAX3 fusion protein Ag0477 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name paired box 3
Synonyms
Calculated Molecular Weight 120 kDa
Observed Molecular Weight 56 kDa
GenBank Accession NumberBC114363
Gene Symbol PAX3
Gene ID (NCBI) 5077
RRIDAB_670479
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDP23760
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PAX3, a transcription factor and multifunctional regulatory protein, is normally expressed during embryonic development. In the nervous system, PAX3 is involved in neural tube closure, neural crest development, and peripheral neuron differentiation. In the present study, PAX3 was reported as a novel regulator of GFAP transcription, and the overexpression and suppression of PAX3 could inhibit and promote NSC differentiation, respectively. In muscle development, PAX3 ensures the survival of myogenic progenitor cells with Pax3-expressing progenitors giving rise to both skeletal and smooth muscle cells. PAX3 also has a well-established role in the development of melanocytes during embryogenesis, and has recently been characterized as a molecular switch in the mature melanocyte. Mutations in PAX3 can cause Waardenburg syndrome.