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验证数据展示

  • IHC staining of rat brain using 51036-2-AP (same clone as 51036-2-PBS)

    IHC staining of rat brain using 51036-2-AP (same clone as 51036-2-PBS)

    Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 51036-2-AP (PAX3 antibody) at dilution of 1:800 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 51036-2-PBS in a different storage buffer formulation.

  • IHC staining of rat brain using 51036-2-AP (same clone as 51036-2-PBS)

    IHC staining of rat brain using 51036-2-AP (same clone as 51036-2-PBS)

    Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 51036-2-AP (PAX3 antibody) at dilution of 1:800 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 51036-2-PBS in a different storage buffer formulation.

  • WB analysis of mouse skin using 51036-2-AP (same clone as 51036-2-PBS)

    WB analysis of mouse skin using 51036-2-AP (same clone as 51036-2-PBS)

    mouse skin tissue were subjected to SDS PAGE followed by western blot with 51036-2-AP (PAX3 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 51036-2-PBS in a different storage buffer formulation.

PAX3 Polyclonal antibody, PBS Only

PAX3 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 51036-2-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

51036-2-PBS targets PAX3 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原 PAX3 fusion protein Ag0477 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 paired box 3
别名
计算分子量 120 kDa
观测分子量 56 kDa
GenBank蛋白编号BC114363
基因名称 PAX3
Gene ID (NCBI) 5077
RRIDAB_670479
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDP23760
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PAX3, a transcription factor and multifunctional regulatory protein, is normally expressed during embryonic development. In the nervous system, PAX3 is involved in neural tube closure, neural crest development, and peripheral neuron differentiation. In the present study, PAX3 was reported as a novel regulator of GFAP transcription, and the overexpression and suppression of PAX3 could inhibit and promote NSC differentiation, respectively. In muscle development, PAX3 ensures the survival of myogenic progenitor cells with Pax3-expressing progenitors giving rise to both skeletal and smooth muscle cells. PAX3 also has a well-established role in the development of melanocytes during embryogenesis, and has recently been characterized as a molecular switch in the mature melanocyte. Mutations in PAX3 can cause Waardenburg syndrome.